This study’s goal is determining the safety of multiple factors that indicate remission in Children from Cron’s disease, including:
- Fecal Microbiota Transplantation (FMT) in children with Crohn’s disease
- Pediatric Crohn’s Disease Activity Index (PCDAI)
- Changes in gut microbial diversity, an underexplored genetic and biological pool
50 grams of stools are donated from healthy donors into the jejunum, the part of the small intestine between the duodenum and ileum, through an upper endoscopy.
The main goal of the trial is safety in children with Crohn’s disease who are in remission. This study is interventional and only studies findings from one group. Safety will be monitored through telephone calls, study visits, and adverse events over 24 weeks. Cron’s disease activity and changes in gut microbiome will also be monitored through through PCDAI scores.
- All sexes, ages 7-21 years old
- Diagnosed with Crohn’s disease
- Remission of disease defined as a PCDAI score less than 10
- Needs an upper GI endoscopy
- Unwilling or unable to provide informed consent
- Pregnancy and breastfeeding
- Subjects with renal and liver dysfunction
- Subjects with immunodeficiency, or who are
- Immunosuppressed due to neoplastic disease or organ transplantation
- Have received or are receiving chemotherapy
- Diagnosed with HIV.
- Severe food allergies
You may participate in this study at the Children’s Hospital Los Angeles in Los Angeles, California, United States, 90027. If you have any questions or concerns, feel free to contact Sonia Michail, MD at 323-361-1353 or at firstname.lastname@example.org.
This clinical trial is sponsored by the Children’s Hospital Los Angeles and Sonia Michail, MD serves as the Principal Investigator.
Clinical TrialsView All Clinical Trials
The Biologic Onset of Crohn’s Disease: A Screening Study in First Degree Relatives
Early, aggressive diagnostic and therapeutic approaches have proven to improve chances of success in treating many…
Early MRI Prediction of Crohns
Researchers at the Children’s Hospital Medical Center, Cincinnati are translating noncontrast, novel Magnetic…
Corticosteroid Dosage for Crohn’s Disease Flare
The Corticosteroid Dosage for Crohn’s Disease Flare clinical trial compares fixed dosing and weight-based…
Safety and Tolerability of Vorinostat for the Treatment of Moderate-to-Severe Crohn’s Disease
Since the inflammatory bowel disease of Crohn’s disease has no cure, researchers are always attempting to uncover…
Clinical Hypnosis in Pediatric Crohn’s Disease
Certain therapies may improve physical and psychosocial outcomes in patients with Crohn’s Disease. Among these…